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No. 21 BYU will be looking to split its home-and-home series with No. 9 Baylor when the teams meet on Saturday night. Baylor picked up a 38-24 win at home last season, but BYU is favored to avenge that loss during the Week 1 college football schedule. The Bears opened the 2022 season with a 69-10 win over Albany last week, while BYU went on the road and dominated South Florida in a 50-21 final. This game will be played at LaVell Edwards Stadium, which has an elevation of 4,649 feet. Receivers Puka Nacua (ankle) and Gunner Romney (undisclosed) are expected to miss this game for BYU.

Kickoff is set for 10:15 p.m. ET. The Cougars are 2.5-point favorites in the latest BYU vs. Baylor odds from Caesars Sportsbook, while the over/under for total points scored is 54.5. Before making any Baylor vs. BYU picks, you need to see the college football predictions and betting advice from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It enters Week 2 of the 2022 college football season on a 48-37 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on BYU vs. Baylor and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for BYU vs. Baylor:

  • BYU vs. Baylor spread: BYU -2.5
  • BYU vs. Baylor over-under: 54.5 points
  • BYU vs. Baylor picks: See picks here

What you need to know about Baylor

BYU was unable to get enough stops to stay in last year's meeting between these teams, and the Cougars are going to face the same challenge on Saturday night. Baylor quarterback Blake Shapen completed 17 of 20 passes for 214 yards and two touchdowns before resting for most of the second half against Albany last week. The Bears won a school-record 12 games last season, including victories in the Big 12 title game and the Sugar Bowl.

Cougars quarterback Jaren Hall threw for 342 yards and a touchdown against Baylor last year, yet it still wasn't enough to keep his team within two touchdowns. The Bears have won nine consecutive games in the month of September and could be even better offensively this season. They have also covered the spread in five of their last six games, while BYU has only covered three times in its last nine games. 

What you need to know about BYU

Meanwhile, the Cougars also blew out their opponent, South Florida, 50-21 last Saturday in Tampa. They gained 563 yards on offense including 312 on the ground led by RB Christopher Brooks, who accounted for 135 yards and a touchdown on 13 carries. 

The Cougars own a 5-22-1 all time record against ranked opponents. BYU put up a good fight against Baylor in 2021, but ultimately fell 38-24. Hall is looking to build off his 20 touchdown, 5 interception campaign in 2021.

How to make BYU vs. Baylor picks

The model has simulated BYU vs. Baylor 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits well over 50% of the time. You can only see the pick at SportsLine.

So who wins the matchup between Baylor and BYU? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Baylor vs. BYU spread to jump on, all from the advanced model that finished the past six-plus years up nearly $3,500 on its FBS college football picks, and find out.